Weight-centric prevention of cancer

• DOI: 10.1016/j.obpill.2024.100106
• Publication Date: 2024-03-05T03:22:54Z
• Authors: Diego Anazco; Andres Acosta; Elizabeth J. Cath...; Stacy D. D'Andre; Maria D. Hurtado

The link between excess adiposity and carcinogenesis has been well established for multiple malignancies, cancer is one of the main contributors to obesity-related mortality. potential role different weight-loss interventions on risk modification assessed, however, its clinical implications remain be determined. In this review, we present data assessing effect weight loss risk. conducted a comprehensive search relevant literature using MEDLINE, Embase, Web Science, Google Scholar databases studies from inception January 20, 2024. systematic reviews meta-analysis, randomized trials, prospective retrospective observational that address treatment modalities obesity in addition, incorporate opinions experts field medicine oncology regarding as preventative intervention cancer. Intentional achieved through associated with reduced incidence. To date, postmenopausal women population more widely studied, reports indicating protective hormone-dependent malignancies. bariatric studied extensively, showing significant reduction incidence mortality, surgery certain specific types conflicting or limited. Medical nutrition therapy, exercise, antiobesity medication, interventions, might lead loss-dependent independent factors. Further evidence needed better determine which benefit most, amount required provide clinically effect.