DGUOK-AS1 acts as a tumor promoter through regulating miR-204-5p/IL-11 axis in breast cancer

• DOI: 10.1016/j.omtn.2021.10.018
• Publication Date: 2021-10-22T05:51:58Z
• Authors: Yiran Liang; Fangzhou Ye; Yajie Wang; Yalun Li; Yaming Li; Xiaojin Song; Dan Luo; Li Long; Dianwen Han; Ying Liu; Zekun Wang; Bing Chen; Wenjing Zhao; Lijuan Wang; Qifeng Yang
• Keywords: 0303 health sciences; 03 medical and health sciences; breast cancer; miR-204-5p; IL11; Original Article; progression; Therapeutics. Pharmacology; RM1-950; DGUOK-AS1; 3. Good health

Breast cancer is one of the most lethal malignancies among women; however, underlying molecular mechanism involved in progression and metastasis breast remains unclear. Numerous studies have confirmed that long noncoding RNAs are abnormally expressed play crucial roles cell proliferation metastasis. In study, we evaluated functional role detailed DGUOK-AS1 knockdown suppressed proliferation, migration, invasion cells vitro vivo. Mechanistically, miR-204-5p was identified as an inhibitory target DGUOK-AS1, which served a tumor suppressor cancer. Significantly, found ectopic expression could counteract DGUOK-AS1-mediated promotion Moreover, IL-11 to be downstream miR-204-5p, protect from miR-204-5p-mediated degradation. overexpression promoted angiogenesis, macrophage mediating by increased secretion IL-11, extremely important for progression. Collectively, our reveal DGUOK-AS1/miR-204-5p/IL-11 axis plays significant cancer, might novel biomarker therapeutic