Unlocking the therapeutic potential of locked nucleic acids through lipid nanoparticle delivery

• DOI: 10.1016/j.omtn.2024.102224
• Publication Date: 2024-05-20T05:56:54Z
• Authors: Shahd Qassem; Dor Breier; Gonna Somu Naidu; Inbal Hazan-Halevy; Dan Peer
• Keywords: 0303 health sciences; 03 medical and health sciences; MT: Oligonucleotides: Therapies and Applications; Therapeutics. Pharmacology; RM1-950; Review; lipid nanoparticles; antisense oligonucleotides; gene delivery; genetic medicine; locked nucleic acids

Locked nucleic acids (LNAs) are a subtype of antisense oligonucleotides (ASOs) that characterized by bridge within the sugar moiety. LNAs owe their robustness to this chemical modification, which as name suggests, locks it in one conformation. This perspective includes two components: general overview on ASOs from side and delivery issues focusing lipid nanoparticles (LNPs) other side. Throughout, screening ongoing clinical trials involving is given, well take versatility challenges using LNAs. Finally, we highlight potential LNPs carriers for successful