The crosstalk between non-coding RNAs and cell-cycle events: A new frontier in cancer therapy

• DOI: 10.1016/j.omton.2024.200785
• Publication Date: 2024-02-29T07:17:24Z
• Authors: Anup S. Pathania; Haritha Chava; Ramesh Balusu; Anil K. Pasupulati; Don W. Coulter; Kishore B. Challa...
• Keywords: Restriction point; Cyclin A; Polo-like kinase; Cyclin-dependent kinase 6

The cell cycle comprises sequential events during which a duplicates its genome and divides it into two daughter cells. This process is tightly regulated to ensure that the receives identical copied chromosomal DNA any errors in replication are correctly repaired. Cyclins their enzyme partners, cyclin-dependent kinases (CDKs), critical regulators of G M phase transitions cycle. Mitogenic signals induce formation cyclin/CDK complexes, resulting phosphorylation activation CDKs. Once activated, complexes phosphorylate specific substrates drive forward. inactivation cyclin-CDK controlled by activating inactivating induced proteins. noncoding RNAs (ncRNAs), do not code for proteins, regulate proteins at transcriptional translational levels, thereby controlling expression different phases. Deregulation ncRNAs can cause abnormal patterns regulating abnormalities regulation cancer development. review explores how ncRNA dysregulation disrupt division balance discusses potential therapeutic approaches targeting these control treatment.