One health clones of multidrug-resistant Escherichia coli carried by synanthropic animals in Brazil

• DOI: 10.1016/j.onehlt.2022.100476
• Publication Date: 2022-12-21T17:05:57Z
• Authors: Elder Sano; Fernanda Esposito; Herrison Fontana; Bruna Fuga; Adriana Cardenas-...; Quézia Moura; Brenda Cardoso; Gladyston C.V. Costa; Tatiana C.M. Bosq...; Juliana A. Sinhorini; Eduardo de Masi; Caroline C. Aires; Nilton Lincopan
• Keywords: Resistome; Disease reservoir

WHO priority pathogens have disseminated beyond hospital settings and are now being detected in urban wild animals worldwide. In this regard, synanthropic such as pigeons (Columba livia) rodents (Rattus rattus, Rattus norvegicus Mus musculus) of interest to public health due their role reservoirs that can cause severe diseases. These usually live highly contaminated environments frequent interactions with humans, domestic animals, food chain, becoming sentinels anthropogenic activities. study, we report genomic data Escherichia coli strains selected for ceftriaxone ciprofloxacin resistance, isolated from black rats. Genomic analysis revealed the occurrence international clones belonging ST10, ST155, ST224 ST457, carrying a broad resistome beta-lactams, aminoglycosides, trimethoprim/sulfamethoxazole, fluoroquinolones, tetracyclines and/or phenicols. SNP-based phylogenomic investigation confirmed clonal relatedness high-risk lineages circulating at human-animal-environmental interface globally. Our results confirm dissemination CTX-M-positive E. Brazil, highlighting potential these infection sources hotspot clinically relevant resistance genes, which is critical issue within One Health perspective.