Detection of anti-HEV antibodies but no molecular positivity in dogs in the Campania region, southern Italy

• DOI: 10.1016/j.onehlt.2024.100724
• Publication Date: 2024-04-08T15:53:52Z
• Authors: G. Ferrara; U. Pagnini; E. Improda; R. Ciarcia; A. Parisi; F. Fiorito; G. Della Valle; G. Iovane; S. Montagnaro
• Keywords: Hepatitis E Virus

Paslahepevirus balayani genotypes 3 and 4 (HEV-3 4) have zoonotic potential can be transmitted to humans animals through the consumption of contaminated raw or undercooked meat. Although it has been demonstrated that dogs are susceptible infection produce specific antibodies, epidemiological role this species is not yet well defined. This study aimed evaluate circulation HEV at serological molecular level in dog population Campania region, southern Italy. A total 231 were sampled, divided according several variables (sex, age, origin, lifestyle, location, size, breed), tested for presence antibodies using a commercial multi-species ELISA. 197 blood samples 170 stool with two PCRs order detect viral RNA. 19 out seropositive, obtaining an exposure (8.2%) similar observed other European countries. The univariate multivariate analysis revealed wide stray from province Salerno. All methods negative. Defining domestic carnivores continues "one health" challenge, although appears they do eliminate virus therefore pose danger humans. In absence evidence, advisable continue carry surveillance also animals, which, due ethological characteristics their position food chain, could predisposed being exposed HEV.