Emerging multi-drug resistant and extended-spectrum β-lactamase (ESBL)-positive enterotoxigenic E. coli (ETEC) clones circulating in aquatic environments and in patients

• DOI: 10.1016/j.onehlt.2025.100968
• Publication Date: 2025-01-10T17:26:11Z
• Authors: Enrique Joffré; Alberto J. Martín...; Annie Justh de Ne...; Astrid von Mentzer; Åsa Sjöling
• Keywords: Enterotoxigenic Escherichia coli

Diarrheal disease pathogens often spread through water-borne routes. Enterotoxigenic Escherichia coli (ETEC) is a major bacterial agent causing diarrheal in children, adults, and travelers endemic areas. In addition, ETEC responsible for outbreaks of water food-borne gasteroenteritis globally, isolates also show robust survival capacity various environmental settings, including aquatic environments. During the last decade, studies have indicated rapid increase multi-drug resistant extended-spectrum β-lactamase (ESBL)-positive human-specific strains. These been found both sources human patients, warranting urgent need focused monitoring antibiotic resistance development ETEC. Whole genome sequencing (WGS) from environmental, animal, enables silico surveillance emerging pathogenic This method allows re-analysis genomic data, aiding identification new variants clones. By integrating data diverse inclusing sequenced isolates, we that certain clonal lineages e.g., those expressing toxin-colonization factor profiles STp/CS6, LT STh/CS2 + CS3, STh/CFA/I are more at risk to develop than other lineages. Comparizon multi-locus sequence types papers with WGS ST182, ST4, ST2332 ST be We conclude further on ETEC/E. genomes needed enhance our understanding dynamics evolution, relation virulence clinical isolates.