Evaluation of SOX2 as a potential marker for ameloblastic carcinoma

• DOI: 10.1016/j.oooo.2014.01.017
• Publication Date: 2014-01-20T17:00:40Z
• Authors: Yu Lei; Jumana M. Jaradat; Adepitan Owosho; Kehinde E. Adebiyi; Kelley S. Lybrand; Brad W. Neville; Susan Müller; Elizabeth A. Bilo...
• Keywords: Ameloblastoma; Immunoenzyme Techniques; 0301 basic medicine; 03 medical and health sciences; Microscopy, Fluorescence; SOXB1 Transcription Factors; Biomarkers, Tumor; Humans; Jaw Neoplasms; Sensitivity and Specificity; 3. Good health

Ameloblastic carcinoma often poses diagnostic challenges in its separation from benign ameloblastoma with atypical cytologic features or an unusual clinical course. This study aimed to determine whether SOX2 (sex determining region-Y-related high mobility group box 2), a protein expressed the epithelial basal proliferative zone dentigerous cysts, is marker for ameloblastic as well high-grade transformation neoplasms.Immunoperoxidase stains were performed according standard protocol. Immunostains interpreted independently by 3 pathologists, and scores recorded based on percentage of staining intensity cells interest.The diffuse strong nuclear pattern has 86.4% specificity (19 22) indicate presence 76.9% sensitivity (10 13) comparison counterparts (P = .0021). Although previously shown neoplasms, calretinin weakly positive few 50% (5 10) 43% (3 7) little value highlighting change .36).The suggestive process neoplasms. Numerous aggregates harboring dense stain should raise concern malignancy.