Differential Expression of Myosin Heavy Chain Isoforms between Abductor and Adductor Muscles in the Human Larynx

• DOI: 10.1016/j.otohns.2003.09.009
• Publication Date: 2004-02-26T13:25:52Z
• Authors: Zhao‐Bo Li; Mohamed Lehar; Hideki Nakagawa; Joseph Foon Yoong...; Paul W. Flint
• Keywords: Adductor muscles

OBJECTIVE This study examines the differential expression of myosin heavy chain (MyHC) components in human laryngeal muscle groups. STUDY DESIGN A battery monospecific monoclonal antibodies Western blots was used to determine IIX, extraocular‐specific (EOM), and IIB MyHCs for thyroarytenoid (TA), vocalis (VOC), lateral cricoarytenoid (LCA), cricothyroid (CT), posterior (PCA) muscles obtained from fresh cadaver specimens. RESULTS Fast IIX MyHC only expressed TA, VOC, LCA muscles. IIA slow were all including CT PCA. The with mixed phonatory respiratory function PCA did not express MyHC. 2 isoforms associated highest speeds contraction rat muscle, namely, EOM MyHC, detected Novel bands SDS‐PAGE gels or using a broad specificity antibody. CONCLUSION profile differs that observed extraocular masticator muscles, other mammalian species. Our data demonstrate is primarily affecting glottic closure absent SIGNIFICANCE higher percentage expected impart high speed shortening TA absence respiratory/phonatory (CT) further supports inference physiologic difference between reflected molecular composition contractile protein.