Photoacoustic oxygenation imaging to identify ischemia/hypoxia injury and necrosis of intestine after acute intussusception: A comparative study with CDFI/CEUS

• DOI: 10.1016/j.pacs.2025.100706
• Publication Date: 2025-03-01T16:20:57Z
• Authors: Hualin Yan; Zehui Gou; Hong Wang; Xiaoxia Zhu; Juxian Liu; Wenwu Ling; Lin Huang; Yan Luo
• Keywords: Hypoxia

Acute intussusception is a pediatric abdominal emergency that requires immediate diagnosis and treatment. However, accurately identifying bowel necrosis non-invasively remains challenging with conventional sonography. In our study, we investigated the potential of photoacoustic imaging (PAI) as an innovative method for assessing ischemia/hypoxia injury intestinal in cases acute intussusception. Using PAI, measured oxygen saturation (sO2) levels total hemoglobin (HbT) various models at different time points. Additionally, evaluated blood supply using color Doppler flow (CDFI) contrast-enhanced ultrasound (CEUS). Based on histopathological results, sO₂ by PAI demonstrated optimal diagnostic performance both necrosis, AUC values 0.997 0.982, respectively, while CDFI CEUS showed relatively high necrosis. conclusion, represents promising, non-invasive modality