The clinical experience of surgical treating 9 cases of gastrinoma

• DOI: 10.1016/j.pan.2015.12.112
• Publication Date: 2016-02-01T03:00:47Z
• Authors: Xing Liang; Yang-liu Ou; Jun Hao; Xian-gui Hu; Gang Jin; Rui Liu; Yi-jie Zhang; An-an Liu; Dan-lei Chen; Liang Tang; Li-gang Shi; Jun Chen; Cheng-hao Shao

s / Pancreatology 16 (2016) S1eS63 S36 2R group and A group comparison, the methylation level of the methylation site-1 of IL-1a gene increased(P 0.05), and IL-1a immunohistochemical score in the acini tissue of the pancreas was lower than in A group(P>0.05). The methylation level of the methylation site-1 and site-2 of IL-10 gene reduced (P 0.05), and IL-10 immunohistochemical score in the acini and the interstitial tissue of the pancreas was higher than in A group (P<0.05). The histological score of the pancreas in R group was lower than in A group(P<0.05).The DNA methylation level of IL-1a gene reduced, and the DNA methylation level of IL-10 gene increased for a 8-week history of alcohol exposure. In pancreatic tissue, IL-1a protein expression increased, and IL-10 protein expression decreased. The cooked rhuarb can reduce the influence of alcohol exposure to regulate the inflammatory response. Finally:1Themethylation level of the methylation site-1 of IL-1a gene reduced for a 8-week history of alcohol exposure, and the methylation level of the methylation site-1 of IL-10 gene increased. IL-1a immunohistochemical score in the acini tissue of the pancreas tissue of the pancreas increased, and IL-10 immunohistochemical score in the acini tissue of the pancreas reduced. Alcohol had no obvious effect on the histological score of the pancreas. Alcohol may increase the inflammatory response and inflammatory injury in acute pancreatitis by reducing the methylation level of IL-1a gene and increasing the methylation level of IL-10 gene. 2 The methylation level of the methylation site-1 of IL-1a gene increased for 5-week history of cooked rhubarb-fed, and IL-1a immunohistochemical score in the acini tissue of the pancreas reduced. The methylation level of the methylation site-1of IL-10 gene reduced for 5week history of cooked rhubarb-fed, and IL-10 immunohistochemical score in the acini and the interstitial tissue of the pancreas increased The histological score of the pancreas reduced. Cooked rhuarb regulate inflammatory cytokine expression in AP to reduce inflammatory injury by affecting the methylation level. Conclusion: IL-1a DNA hypomethylation and IL-10 DNA hypermethylation induced by alcohol induced the imbalances of the pro-inflammatory/anti-inflammatory response of pancreas. Cooked rhubarbmay reduce the expression of IL-1a and increase the expression of IL-10 to restore the balance of pro-inflammatory/anti-inflammatory response by increasing the methylation level of IL-1a gene and reducing the methylation level of IL-10 gene.