Anxiolytic-like activity and GC–MS analysis of (R)-(+)-limonene fragrance, a natural compound found in foods and plants

• DOI: 10.1016/j.pbb.2012.09.005
• Publication Date: 2012-09-18T05:03:11Z
• Authors: Naiana G.P.B. Lima; Damião P. De Sousa; Flávia Cristina F...; Mateus F. Alves; Fábio S. De Souza; Rui O. Macedo; Ricardo B. Cardoso; Liana Clébia S.L....; Margareth de Fáti...; Reinaldo Nóbrega ...
• Keywords: Aromatherapy; Elevated plus maze; Terpene

The traditional use of essential oils in aromatherapy has offered numerous health benefits. However, few scientific studies have been conducted with these to confirm their therapeutic efficacy. (+)-Limonene is a chemical constituent various bioactive oils. present study reports on the anxiolytic-like effects (+)-limonene an elevated maze model anxiety mice. At concentrations 0.5% and 1.0%, (+)-limonene, administered mice by inhalation, significantly modified all parameters evaluated plus test. pharmacological effect inhaled (1%) was not blocked flumazenil. Analysis using gas chromatography-mass spectrometry (GC-MS) showed its volatility be high. These data suggest possible connections between indicate that could used as antianxiety agent.