The clinical use of ultra – Wide field imaging and intravenous fluorescein angiography in infants with retinopathy of prematurity

• DOI: 10.1016/j.pdpdt.2021.102658
• Publication Date: 2021-11-26T15:50:48Z
• Authors: Murat Gunay; Ersagun Tugcugil; Ahmet Mehmet Somuncu; Mehmet Kola; Adem Turk; Dilek Uzlu; Busra Kose; Hidayet Erdol
• Keywords: 0301 basic medicine; 03 medical and health sciences; Photochemotherapy; Infant, Newborn; Humans; Infant; Retinal Vessels; Female; Retinopathy of Prematurity; Fluorescein Angiography; Retrospective Studies; 3. Good health

To investigate the potential benefits and practicality of ultra - wide field (UWF) imaging and intravenous UWF fluorescein angiography (IV UWF - FA) in infants with retinopathy of prematurity (ROP) using an Optos® California device.This retrospective study involved 46 infants with a history of ROP who underwent UWF imaging with or without IV UWF - FA. ROP characteristics were identified using UWF color imaging. Retinal vascular findings following treatment were also assessed at IV UWF - FA analysis. All imaging sessions were performed under topical anesthesia without sedation. Main outcomes were the appearance of ROP at UWF color imaging and IV UWF-FA analysis, including status of ROP, neovascularizations, presence of plus disease, retinal vascular details, and resolution after treatment.Seven (three girls) of the 46 infants (22 girls) underwent IV UWF-FA. Twelve IV UWF-FA sessions were performed in total. The oldest infant during IV UWF-FA analysis was at 55 postmenstrual weeks. Clinical characteristics of disease were easily identified at UWF color imaging. IV UWF-FA images also clearly revealed non-perfused retinal areas, fluorescein leakage, macular edema, retinal vascular abnormalities, and the status of the peripheral vascular termini. Complications of IV UWF-FA occurred in one infant in the form of patchy yellow skin discoloration around the injection site which completely disappeared on the first day following the procedure.Providing a high resolution panoramic view of the retina in a single image capture with no need for contact with the cornea appear to represent potential advantages of UWF imaging in infants with ROP. IV UWF-FA also seems to be a safe procedure which can be performed under topical anesthesia and that shows detailed retinal vascular alterations in patients with ROP.