Evaluation of photodynamic therapy efficacy vs. conventional antifungal therapy in patients with poor-fitting dentures suffering from denture stomatitis. A prospective clinical study

• DOI: 10.1016/j.pdpdt.2023.103913
• Publication Date: 2023-12-02T23:58:59Z
• Authors: Dragana Rakasevic; Jelena Marinkovic; Bojan Rakonjac; Marion Arce; Ena Joksimovic; Jovana Markovic; Milan Kulic; Milos Hadzi-Mihai...; Aleksa Markovic
• Keywords: Candida krusei

The long-term use of antifungal therapy in denture stomatitis (DS) treatment could be accompanied by antifungal-resistant strain onset, leading to compromised therapeutic procedure and disease reappearance. Photodynamic (PDT) has shown the ability eradicate oral infections resistance strains. This prospective clinical study aimed assess PDT's effectiveness compared conventional on microbiological parameters patients with DS without wear during follow-ups. Forty-two diagnosed were randomly assigned one-session single PDT application (test group) or (control group). Clinical assessed analyzed before at 3rd, 15th, 30th day following treatments. Microbiological samples a Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. data was statistically analyzed. Prior treatment, Candida species, including C. albicans (100%), glabrata (33%), tropicalis (31%), krusei (31%) isolated all patients. Both procedures demonstrated significant reduction follow-up time intervals (p < 0.05). However, displayed periods improved considerably test group control 3rd 15th follow-up. One-session improvement both outcomes short-term period, resulting complete spp. eradication therapy.