Disorders of Neuronal Migration/Organization Convey the Highest Risk of Neonatal Onset Epilepsy Compared With Other Congenital Brain Malformations

• DOI: 10.1016/j.pediatrneurol.2021.11.005
• Publication Date: 2021-11-12T06:56:28Z
• Authors: Roxanne Simmons; Ariadna Borras Ma...; James Barkovich; Adam L. Numis; Maria Roberta Cilio; Orit A. Glenn; Dawn Gano; Elizabeth E. Rogers; Hannah C. Glass
• Keywords: Male; Antiseizure medication (ASM); Neonatal encephalopathy; Nervous System Malformations; Infant, Newborn, Diseases; Congenital abnormalities; 03 medical and health sciences; 0302 clinical medicine; Cell Movement; Neurocritical care; Prevalence; Humans; EEG; Retrospective Studies; Epilepsy; Infant, Newborn; Brain; Electroencephalography; Neonatal seizures; Seizure; 3. Good health; Electroencephalogram; Female

BackgroundAlthough seizures in neonates are common and often due to acute brain injury, 10-15% unprovoked from congenital malformations. A better understanding of the risk neonatal-onset epilepsy by type malformation is essential for counseling monitoring.MethodsIn this retrospective cohort study, we evaluated 132 with malformations their epilepsy. Malformations were classified into one five categories based on imaging patterns prenatal or postnatal imaging. Infants monitored continuous video EEG (cEEG) encephalopathy paroxysmal events addition abnormal neuroimaging.ResultsSeventy-four (56%) underwent monitoring, 18 (14%) diagnosed The highest prevalence was disorders neuronal migration/organization (9/34, 26%; 95% confidence interval [CI] = 13-44%), followed early prosencephalic development (6/38, 16%; CI 6-31%), complex total (2/16, 13%; 2-38%), midbrain/hindbrain (1/30, 3%; 0-17%). Of epilepsy, 5 (28%) had only electrographic seizures, 13 (72%) required treatment two more antiseizure medicines (ASMs), 7 (39%) died within neonatal period.ConclusionOur results demonstrate that represent highest-risk group early-onset Seizures frequently only, require multiple ASMs, portend a high mortality rate. These support American Clinical Neurophysiology Society recommendations monitoring during period infants