A randomized pilot study comparing the role of PEEP, O 2 flow, and high-flow air for weaning of ventilatory support in very low birth weight infants

• DOI: 10.1016/j.pedneo.2017.02.005
• Publication Date: 2017-09-06T07:22:25Z
• Authors: Chang-Yo Yang; Mei-Chin Yang; Shih-Ming Chu; Ming-Chou Chiang; Reyin Lien
• Keywords: Male; Adolescent; Continuous Positive Airway Pressure; Infant; Pilot Projects; Pediatrics; RJ1-570; 3. Good health; Oxygen; Positive-Pressure Respiration; 03 medical and health sciences; Cross-Sectional Studies; 0302 clinical medicine; Child, Preschool; Humans; Infant, Very Low Birth Weight; Female; Retinopathy of Prematurity; Prospective Studies; Child; Ventilator Weaning; Bronchopulmonary Dysplasia

There is a lack of evidence to guide step-wise weaning positive pressure respiratory support for premature infants. This study sought compare the efficacy three protocols we designed facilitate very low birth weight (VLBW, less than 1500 g) preterm infants from nasal continuous airway (NCPAP) support. was prospective, randomized, controlled trial VLBW who received ventilatory in our neonatal intensive care unit (NICU) April 2008 through March 2009. When these were weaned CPAP as their last step support, they would be randomly assigned one following groups further methods (M): (M1) group, (M2) O2 flow and (M3) air group. The time period needed wean off any kind well likelihood developing relevant prematurity related morbidities, compared among patients using different modalities. 181 enrolled study. Their gestational age (GA) (BW) 29.1 ± 2.5, 28.7 2.4, 2.4 (mean SD) weeks 1142 232, 1099 234, 1083 219 g, M1, M2 M3, respectively. (period) 16.0 10.0 days (M1), 11.6 6.4 (M2), 15.0 8.9 (M3), respectively (p = .033). Incidence retinopathy (ROP) bronchopulmonary dysplasia (BPD) both significantly higher group .048). Although oxygen shortens time, it may increase risks BPD ROP, known toxicity. Unless infant has O2-dependent, clinicians should consider or just splinting with no at all when NCPAP.