Dopamine D2 receptors in pyramidal neurons in the medial prefrontal cortex regulate social behavior

• DOI: 10.1016/j.phrs.2023.107042
• Publication Date: 2023-12-22T16:45:25Z
• Authors: Hao Chen; Xing-Xing Xiong; Shi-Yang Jin; Xiao-Ying He; Xiao-Wen Li; Jian-Ming Yang; Tian-Ming Gao; Yi-Hua Chen
• Keywords: Brain stimulation reward

Drugs acting on dopamine D2 receptors are widely used for the treatment of several neuropsychiatric disorders, including schizophrenia and depression. Social deficits a core symptom these disorders. Pharmacological manipulation (Drd2), Gi-coupled subtype receptors, in medial prefrontal cortex (mPFC) has shown that Drd2 is implicated social behaviors. However, type neurons expressing mPFC underlying circuit mechanism regulating behaviors remain largely unknown. Here, we show were mainly expressed pyramidal activation Gi-pathway