Dopamine D2 receptors in pyramidal neurons in the medial prefrontal cortex regulate social behavior

Brain stimulation reward
DOI: 10.1016/j.phrs.2023.107042 Publication Date: 2023-12-22T16:45:25Z
ABSTRACT
Drugs acting on dopamine D2 receptors are widely used for the treatment of several neuropsychiatric disorders, including schizophrenia and depression. Social deficits a core symptom these disorders. Pharmacological manipulation (Drd2), Gi-coupled subtype receptors, in medial prefrontal cortex (mPFC) has shown that Drd2 is implicated social behaviors. However, type neurons expressing mPFC underlying circuit mechanism regulating behaviors remain largely unknown. Here, we show were mainly expressed pyramidal activation Gi-pathway
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