peu-MIR2916-p3-enriched garlic exosomes ameliorate murine colitis by reshaping gut microbiota, especially by boosting the anti-colitic Bacteroides thetaiotaomicron

• DOI: 10.1016/j.phrs.2024.107071
• Publication Date: 2024-01-11T16:46:45Z
• Authors: Xiaoyuan Wang; Yueyue Liu; Xinyue Dong; Tianchi Duan; Chennan Wang; Lu Wang; Xingbin Yang; Honglei Tian; Ting Li
• Keywords: Bacteroides thetaiotaomicron; Dysbiosis; Proinflammatory cytokine

Plant-derived exosome-like nanoparticles (ELNs) have drawn considerable attention for oral treatment of colonic diseases. However, the roles ELNs derived from garlic on colitis remain unclear. Here, we demonstrate that (GELNs), with desirable particle sizes (79.60 nm) and trafficking large amounts functional proteins microRNAs, stably roam in gut confer protection against ulcerative (UC). In mice DSS-induced colitis, orally administered GELNs effectively ameliorated bloody diarrhea, normalized production proinflammatory cytokines, prevented barrier impairment. Mechanistically, were taken up by microbes reshaped microbiota dysbiosis, which Bacteroides was dominant respondent genus upon treatment. Notably, GELNs-enriched peu-MIR2916-p3 specifically promoted growth thetaiotaomicron, an intestinal symbiotic bacterium palliative effects colitis. Our findings provide new insights into medicinal application highlight their potential as natural nanotherapeutic agents preventing treating UC.