Insights into the role of derailed endocytic trafficking pathway in cancer: From the perspective of cancer hallmarks

• DOI: 10.1016/j.phrs.2024.107084
• Publication Date: 2024-01-29T16:47:04Z
• Authors: Hongjie Guo; Chen Zhou; Mingming Zheng; Jie Zhang; Honghai Wu; Qiaojun He; Ling Ding; Bo Yang
• Keywords: Cell Signaling

The endocytic trafficking pathway is a highly organized cellular program responsible for the regulation of membrane components and uptake extracellular substances. Molecules internalized into cell through endocytosis will be sorted degradation or recycled back to membrane, which determined by series sorting events. Many receptors, enzymes, transporters on are strictly regulated process, thus has profound effect homeostasis. However, process typically dysregulated in cancers, leads aberrant retention receptor tyrosine kinases immunosuppressive molecules loss adhesion protein, as well excessive nutrients. Therefore, hijacking an important approach tumor cells obtain advantages proliferation invasion, evade immune attack. Here, we summarize how triggers tumorigenesis progression from perspective several typical cancer hallmarks. impact therapy efficacy also discussed.