Ononin promotes radiosensitivity in lung cancer by inhibiting HIF-1α/VEGF pathway

• DOI: 10.1016/j.phymed.2023.155290
• Publication Date: 2023-12-20T02:30:45Z
• Authors: Yi-Ming Zhang; Zhi-Ming Miao; Ya-Ping Chen; Zhang-Bo Song; Yang-Yang Li; Zhi-Wei Liu; Gu-Cheng Zhou; Jing Li; Liang-Liang Shi; Yan Chen; Shang-Zu Zhang; Xiaohui Xu; Jin-Peng He; Ju-Fang Wang; Li-Ying Zhang; Yong-Qi Liu
• Keywords: Calycosin

In our previous study, we provided evidence that Astragalus mongholicus Bunge(AM) and its extracts possess a protective capability against radiation-induced damage, potentially mediated through the reduction of reactive oxygen species (ROS) nitric oxide (NO). However, were pleasantly surprised to discover during experimentation AM not only offers protection radiation damage but also exhibits sensitization effect. This effect may be attributed specific small molecule present in known as ononin. Currently, sensitizers are predominantly found nitrazole drugs nanomaterials, with no existing reports on properties ononin, nor underlying mechanism.