Anti-aging effects of medicinal plants and their rapid screening using the nematode Caenorhabditis elegans

• DOI: 10.1016/j.phymed.2024.155665
• Publication Date: 2024-04-28T00:37:24Z
• Authors: Xiaodan Chen; Faranak Bahramimehr; Nasim Shahhamzehei; Huangjie Fu; Siyi Lin; Hanxiao Wang; Changyu Li; Thomas Efferth; Chunlan Hong
• Keywords: Sirolimus; Aging; Plants, Medicinal; Plant Extracts; Animals; Humans; Caenorhabditis elegans; Metformin; Signal Transduction

Aging is the primary risk factor of most chronic diseases in humans, including cardiovascular diseases, osteoporosis and neurodegenerative these extensively damage quality life for elderly individuals. a multifaceted process with numerous factors influencing it. Efficient model organisms are essential research development anti-aging agents, particularly while investigating pharmacological mechanisms. This review discusses application Caenorhabditis elegans studying aging its related signaling pathways, presents an overview studies exploring mechanism screening agents C. elegans. Additionally, summarizes clinical trials to inspire new medications. Literature was searched, analyzed, collected using PubMed, Web Science, Science Direct. The search terms used were "anti-aging", "medicinal plants", "synthetic compounds", "C. elegans", "signal pathway", etc. Several combinations keywords used. Studies conducted or humans included. Articles excluded, if they on silico vitro could not offer effective data. Four compounds mainly derived through synthesis (metformin, rapamycin, nicotinamide mononucleotide, alpha-ketoglutarate) four active ingredients chiefly obtained from plants (resveratrol, quercetin, Astragalus polysaccharide, ginsenosides) introduced emphatically. These exhibit potential effects preclinical studies. investigation their mechanisms can benefit use Medicinal provide valuable resource treating diseases. A wide source raw materials particular plant medicinal having meet diverse pharmaceutical requirements, such as immunomodulatory, anti-inflammation alleviating oxidative stress. possesses advantages scientific short cycle, small size, easy maintenance, genetic tractability conserved biological processes aging. be efficient rapid evaluation slow down