Chronic scream sound exposure alters memory and monoamine levels in female rat brain

• DOI: 10.1016/j.physbeh.2014.06.012
• Publication Date: 2014-06-18T21:14:05Z
• Authors: Lili Hu; Xiaoge Zhao; Juan Yang; Lumin Wang; Yang Yang; Tusheng Song; Chen Huang
• Keywords: 0301 basic medicine; Memory Disorders; Body Weight; Brain; Organ Size; 3. Good health; Rats, Sprague-Dawley; Random Allocation; 03 medical and health sciences; Acoustic Stimulation; Adrenal Glands; Chronic Disease; Animals; Biogenic Monoamines; Female; Vocalization, Animal; Corticosterone; Maze Learning; Stress, Psychological; Spatial Memory

Chronic scream sound alters the cognitive performance of male rats and their brain monoamine levels, these stress-induced alterations are sexually dimorphic. To determine the effects of sound stress on female rats, we examined their serum corticosterone levels and their adrenal, splenic, and thymic weights, their cognitive performance and the levels of monoamine neurotransmitters and their metabolites in the brain. Adult female Sprague-Dawley rats, with and without exposure to scream sound (4h/day for 21 day) were tested for spatial learning and memory using a Morris water maze. Stress decreased serum corticosterone levels, as well as splenic and adrenal weight. It also impaired spatial memory but did not affect the learning ability. Monoamines and metabolites were measured in the prefrontal cortex (PFC), striatum, hypothalamus, and hippocampus. The dopamine (DA) levels in the PFC decreased but the homovanillic acid/DA ratio increased. The decreased DA and the increased 5-hydroxyindoleacetic acid (5-HIAA) levels were observed in the striatum. Only the 5-HIAA level increased in the hypothalamus. In the hippocampus, stress did not affect the levels of monoamines and metabolites. The results suggest that scream sound stress influences most physiologic parameters, memory, and the levels of monoamine neurotransmitter and their metabolites in female rats.