The effects of caffeine on alcohol oral self-administration behavior in rats

• DOI: 10.1016/j.physbeh.2020.112966
• Publication Date: 2020-05-19T15:40:49Z
• Authors: Paulo Ricardo Fer...; Felipe Borges Alm...; Maria Manoela Mar...; Carina Fischer Fe...; Luana Freese; Helena Maria Tann...
• Keywords: Self-administration

Caffeine and alcohol are some of the most commonly used psychoactive substances in world, often concomitantly. However, little is known about effect caffeine on consumption. Here, our aim was to investigate co-exposure mixed with self-administration. Thirty-two male thirty-two female Wistar rats were randomly divided into following groups: control, (0.25 mg/mL), (10% v/v) caffeine. After one week training, animals underwent self-administration for 21 days (1 h per day) a fixed ratio 1 (FR1). The forced swimming test (FST) performed before training phase 24 after last session verify abstinence-induced depressive-like behaviors. Our results showed that all consumed lower volume alcohol-containing solution than control solution, presence did not influence this parameter. Females less males but average dose similar. self-administered presented higher immobility FST same solution. These support conclusion moderate doses such as ones from study (approximately 7-8 mg/kg/day) do Additionally, females might be more susceptible effects caused by abstinence use these combination.