Cytotoxic triterpenoids from Chisocheton pentandrus

• DOI: 10.1016/j.phytochem.2021.112759
• Publication Date: 2021-04-09T00:44:35Z
• Authors: Supriatno Salam; Desi Harneti; Rani Maharani; Nurlelasari; Agus Safari; Ace Tatang Hidayat; Ronny Lesmana; Mohamad Azlan Nafiah; Unang Supratman; Thomas Alexander ...; Yoshihito Shiono
• Keywords: Molecular Structure; Humans; Antineoplastic Agents; Biodiversity; Meliaceae; Antineoplastic Agents, Phytogenic; 01 natural sciences; Triterpenes; Taxonomy; 0104 chemical sciences; 3. Good health

Eleven undescribed triterpenoids (pentandrucines A to K) were isolated from the n-hexane extract of the stem bark of Chisocheton pentandrus (Blanco) Merr. These comprised ten undescribed dammarane-type triterpenoids and one undescribed apotirucallane-type triterpenoid. Additionally, two dammarane-type triterpenoids, four apotirucallane-type triterpenoids and two tirucallane-type triterpenoids were also isolated. The chemical structures of pentandrucine A-K, were fully elucidated using 1D and 2D-NMR, and high resolution MS. All of the compounds were evaluated for cytotoxic activity against MCF-7 breast cancer cells in vitro. Melianodiol proved to be the most active with an IC50 of 16.84 μM comparing favourably with Cisplatin (13.2 μM).