Iridoid glycosides and lignans from the fruits of Gardenia jasminoides Eills

• DOI: 10.1016/j.phytochem.2021.112893
• Publication Date: 2021-07-28T12:38:56Z
• Authors: Yan-Gang Cao; Ying-Jie Ren; Yan-Ling Liu; Meng-Na Wang; Chen He; Xu Chen; Xi-Ling Fan; Yan-Li Zhang; Zhi-You Hao; Hong-Wei Li; Xiao-Ke Zheng; Wei-Sheng Feng
• Keywords: Plant Extracts; Fruit; Iridoid Glycosides; Biodiversity; Glycosides; Gardenia; 01 natural sciences; Lignans; Taxonomy; 0104 chemical sciences

Four previously undescribed iridoid glycosides, including two bis-iridoid glycosides, and three undescribed lignans, together with 16 known analogues, were isolated from the fruits of Gardenia jasminoides Eills. Their structures were elucidated on basis of spectroscopic methods, and the absolute configurations of three of the unknown compounds were determined by interpretation of their electronic circular dichroic (ECD) and [α] [Formula: see text] data. The α-glucosidase inhibitory effects of the isolated compounds were evaluated and all the compounds exhibited slightly inhibitory activity with the values of IC50 greater than 50 μM.