Rapid screening of diarylpentanoids from Daphne bholua

• DOI: 10.1016/j.phytochem.2023.113614
• Publication Date: 2023-02-20T01:49:27Z
• Authors: Shu-Hui Dong; Mei-Ya Lian; Jin-Ling Han; Yun-Fei Ai; Xiao-Fang Zhou; Ming Bai; Xiao-Xiao Huang; Shao-Jiang Song
• Keywords: Magnetic Resonance Spectroscopy; Molecular Structure; Acetylcholinesterase; Daphne; 01 natural sciences; 0104 chemical sciences

Fractionation motivated by biological activity screening and NMR characteristic signals analysis led to the isolation of seventeen diarylpentanoids from the whole plant of Daphne bholua Buch.-Ham. ex D. Don, among which nine compounds were undescribed. Their structures and stereochemistry were determined by comprehensive spectroscopic data, J-based configurational analysis, and quantum chemical calculations. The inhibitory potentials of all isolates against acetylcholinesterase were evaluated in vitro and in silico.