Cumulative effect of maternal vascular malperfusion types in the placenta on adverse pregnancy outcomes

• DOI: 10.1016/j.placenta.2022.09.007
• Publication Date: 2022-09-18T21:45:36Z
• Authors: Nadi Arts; Veronique Schiffer; Carmen Severens-R...; Judith Bons; Marc Spaanderman; Salwan Al-Nasiry
• Keywords: Cumulative incidence

Placental vascular disease, characterized by Maternal Vascular Malperfusion (MVM) lesions, is considered to be the underlying cause of pregnancy complications. Aim evaluate relationship between cumulative number MVM lesion types, and adverse pregnancy- neonatal outcomes.This retrospective cohort study included 272 women with singleton gestations who gave birth at a Dutch tertiary hospital 2017 2018 available placental histopathology reports. Analyzed according Amsterdam Workshop Group Consensus Statement, placentas were divided into groups based on lesions: no lesions (n = 124), 1-2 types 124) 3-5 24).The proportion placenta syndrome (PS) was highest (95.8%) in group (p < 0.001). The presence highly associated PS during (aOR 6.81, 95% CI 3.76-12.33). Furthermore, every additional type corresponded threefold increased odds for occurrence 3.00, 2.10-4.29). showed incidence outcomes, lower mean weight, prolonged hospitalization, NICU admissions deaths 6.47, 0.33-127.68), corresponding fourfold death 4.19, 1.39-12.68).A higher strongly an indicating that guidelines should focus also amount monitoring/management subsequent pregnancies.