Associations between the maternal healthy lifestyle score and its individual components during early pregnancy with placental outcomes

• DOI: 10.1016/j.placenta.2023.06.001
• Publication Date: 2023-06-13T06:36:17Z
• Authors: Shevaun M. Teo; Celine M. Murrin; John Mehegan; Alexander Douglass; James R. Hébert; Ricardo Segurado; Cecily C. Kelleher; Catherine M. Phil...
• Keywords: Pregnancy; Placenta; Smoking; Humans; Birth Weight; Female; Healthy Lifestyle; Placentation; 3. Good health

The influence of maternal lifestyle behaviours on placental growth have been investigated individually, but with conflicting results, and their combined effect is under-researched. Therefore, we examined associations between a composite healthy score (HLS), its individual components, during early pregnancy outcomes.Participants included Lifeways Cross-Generational Cohort mother-child pairs (n = 202). A HLS based less inflammatory diet (bottom 40% the energy-adjusted Dietary Inflammatory Index (E-DII™)), moderate-to-vigorous physical activity (MVPA), pre-pregnancy BMI (18.5-24.9 kg/m2), never smoking, non-/moderate alcohol intake was calculated. Quantile regression analysed (and components) measures development (untrimmed weight (PW)) function (birth weight:placental (BW:PW) ratio) at 10th, 25th, 50th, 75th 90th centiles.A more pro-inflammatory positively, smoking heavy consumption were negatively, associated PW median centiles (B: 41.97 g, CI: 3.71, 80.22, p < 0.05; B: -58.51 -116.24, -0.77, -120.20 -177.97, -62.43, 0.05 respectively). Low MVPA inversely BW:PW ratio 10th -0.36, -0.132, -0.29, 0.01 -0.45, -0.728, -0.182, 0.01, Heavy positively centile 0.54, 0.24, 0.85, 0.01). Results sex-stratified analysis provide evidence sexual dimorphism.Associations certain factors, not HLS, (PW) (BW:PW varied by quantiles sex.