Silver(I) and zinc(II) complexes with symmetrical cinnamaldehyde Schiff base derivative: Spectroscopic, powder diffraction characterization, and antimycobacterial studies

• DOI: 10.1016/j.poly.2018.02.024
• Publication Date: 2018-03-15T19:51:17Z
• Authors: Thaeny C. Amaral; Fábio B. Miguel; Mara R.C. Couri; Pedro P. Corbi; Marcos A. Carvalho; Débora L. Campos; Fernando R. Pavan; Alexandre Cuin
• Keywords: Powder diffraction; Tuberculosis; Schiff bases; Metal ions; 540; Cinnamaldehyde; 01 natural sciences; 3. Good health; 0104 chemical sciences

Abstract Silver(I) and zinc(II) complexes with N,N′-bis(trans-cinnamaldehyde)ethane-1,2-diamine (EnCinn) have been synthesized and characterized by elemental analysis, simultaneous thermogravimetric and differential thermal studies (TG-DTA), infrared (IR), 1H and 13C nuclear magnetic resonance (NMR) spectroscopic measurements and electrospray ionization quadrupole time-of-flight mass spectrometry (ESI-QTOF-MS). Crystal and molecular structure descriptions were performed based on powder X-ray diffraction data. The AgEnCinn complex has a polymeric structure where the ligand bridges between two Ag(I) ions, while the ZnEnCinn complex has a monomeric structure with EnCinn acting as chelating ligand. Antimycobacterial assays over Mycobacterium tuberculosis showed the activity of the Ag(I) complex with Minimum Inhibitory Concentration (MIC) value of 22.7 μmol L−1, while the Zn(II) complex was shown to be inactive over the same experimental conditions.