Green coconut water administration potentiates positive correlation between reproductive organs’ weight and sex hormone profile in flutamide induced androgen perturbation in male prepubertal Wistar rats

• DOI: 10.1016/j.prmcm.2024.100372
• Publication Date: 2024-01-25T01:01:09Z
• Authors: Abdulkareem Temit...; Airat Bakare; Ademola Oremosu; Ahmad Tijani; Adedeji Enitan Ad...
• Keywords: Flutamide; Positive correlation

The reproductive system is the chief precursor system, whose germ cell activities lead to emergence of other systems, that work synergistically maintain body homeostasis. Androgen plays an integral role in development and optimal functioning male organs. Green coconut water (Yezi shui) a natural, thirst quenching therapeutic beverage consumed both recreationally medicinally amidst Chinese populace for its diverse health benefits. This study was aimed at investigating action green (GCW) on antiandrogenic effects flutamide sex hormone homeostasis along hypothalamic pituitary gonadal (HPG) axis correlation weight distributions organs: testis, epididymis, prostate seminal vesicle peripubertal Wistar rats. Thirty-six (36) pre-pubertal pups postnatal ages Postnatal day (PND) 11 were purchased, acclimatized, randomly distributed PND 25 into six experimental groups A-F. Group A, B C received distilled water, 25mg/kg 20ml/kg respectively 6 weeks. D E 2 weeks then GCW 10ml/kg 4 weeks, while F concomitantly At end experiment 67, prostate, vesicles, blood sample obtained morphological hormonal evaluations. administration significantly revived organs reduced due anti-androgenic flutamide. More so, increased concentrations intratesticular testosterone follicle stimulating (FSH), it brings moderate threshold luteinizing (LH) concentration treated There evident submission increment organs' correlate with increase hormones profiles. findings from this suggest may be efficient restore imbalance corresponding organ weights which underpin many cases factor infertility.