Aberrant Cadherin11 expression predicts distant metastasis of gastric cancer

• DOI: 10.1016/j.prp.2022.154294
• Publication Date: 2022-12-28T16:48:35Z
• Authors: Hideaki Mita; Hiroto Katoh; Daisuke Komura; Miwako Kakiuchi; Hiroyuki Abe; Hirofumi Rokutan; Koichi Yagi; Sachiyo Nomura; Tetsuo Ushiku; Yasuyuki Seto; Shumpei Ishikawa
• Keywords: Male; 03 medical and health sciences; 0302 clinical medicine; Stomach Neoplasms; Biomarkers, Tumor; Humans; Breast Neoplasms; Neoplasm Metastasis; Prognosis; 3. Good health

The prognosis of gastric cancer (GC) is significantly affected by distant metastases and postoperative recurrences. Bone metastasis one the worst prognostic in GC; however, its molecular mechanisms predictive biomarkers remain elusive. In prostate breast cancers, it has been reported that overexpression Cadherin 11 (CDH11), a mesenchymal cell-cell contact factor, known to be correlated with bone metastasis. Overexpression CDH11 mRNA bulk GC tissues also associated worse prognosis. However, more precise evaluation expression cells necessary establish robust link between metastatic features GC. We performed immunohistochemical analysis 342 cases, which specimens were obtained at time surgery, special focus on aberrant membranous cells. correlations cases statistically investigated. Approximately half investigated showed primary lesions. Aberrant was GCs. Moreover, liver lymph nodes expression. tumor lesions shown biomarker GCs require preventive clinical attention for detection