Prevalence and transmission of extensively drug-resistant Salmonella enterica serovar Kentucky ST198 based on whole-genome sequence in an intensive laying hen farm in Jiangsu, China

• DOI: 10.1016/j.psj.2024.103608
• Publication Date: 2024-03-06T17:11:30Z
• Authors: Bowen Liu; Chuang Meng; Zhenyu Wang; Qing Li; Chen Xu; Xilong Kang; Lei Chen; Fan Wang; Xinan Jiao; Zhiming Pan
• Keywords: Salmonella enterica; Salmonella enteritidis

Salmonella, which is widely distributed in nature, an important zoonotic pathogen affecting humans, livestock, and other animals. Salmonella infection not only hinders the development of livestock poultry-related industries but also poses a great threat to human health. In this study, we collected 1537 samples including weak chicks, dead embryos, fecal environmental from 2020-2023 (for period 1 2 months per year) keep long-term monitor prevalence intensive laying hen farm, 105 strains were isolated with isolation rate 6.83% (105/1537). It revealed significant decrease rates over time (P<0.001). Before 2020, predominant serotype was S. Enteritidis. Kentucky first detected November 2020 their proportion gradually found exceed that Enteritidis since then. isolates various links four regions poultry farm. A total 55 strains, assigned ST198 based on whole genome sequencing. Among them, 54 resistant 12 16 antibiotics, indicating they extensively drug-resistant (XDR). Seventeen antimicrobial resistance genes isolates. For most these isolates, antibiotic phenotypes concordant genotypes. All farm 2020–2023 showed high similarity core-genome SNP-based phylogeny. The traceability analysis introduced through newly purchased flocks. existence XDR substantial risk because multiage management circulation workers Thus, study report China.