Effects of deoxynivalenol contaminated corn distiller's dried grains with solubles on growth performance, body composition, immunological response, and gastrointestinal health in young pullets

• DOI: 10.1016/j.psj.2024.104611
• Publication Date: 2024-11-28T16:33:31Z
• Authors: Deependra Paneru; Milan K. Sharma; Hanyi Shi; Doyun Goo; Venkata S.R. Choppa; Ishwari Gyawali; Revathi Shanmugas...; Woo K. Kim
• Keywords: Gastrointestinal health; Growth performance; Pullets; METABOLISM AND NUTRITION; Immune response; SF1-1100; Deoxynivalenol; Animal culture

Mycotoxins, particularly deoxynivalenol (DON), are common contaminants in feed ingredients such as corn distiller's dried grains with solubles (DDGS) and pose significant risks to poultry health. This study investigated the effects of feeding naturally DON contaminated DDGS on growth performance, body composition, immunological response, gastrointestinal health young pullets. A total 360, 4-week-old Hy-Line W36 pullets were randomly assigned diets increasing levels (0, 5, 10, 15, 20%) over 28 days, resulting dietary concentrations ranging from below limit quantification 15.4 ppm. Diets concentration exceeding 8.9 ppm, corresponding 15% 20% inclusion, resulted significantly lower weight gain (BWG) intake (FI) experimental day 14 compared 5.9 ppm 5 10% groups; P = 0.024 0.007, respectively). Body composition analysis showed a higher tissue fat percentage group (15.4 DON) by inclusion (P 0.021). Immunologically, increase CD4+:CD8+ ratio spleen was observed 0% 0.013), whereas both 15 increased cecal tonsil < 0.001). Additionally, interleukin 1β (IL-1β) expression inclusions 0.002). Gut compromised gut permeability linearly (linear, 0.043), aligning alterations tight junction protein occludin (OCLN; 0.007). Antioxidant responses liver superoxide dismutase (SOD) activity early exposure (day 13, 0.038), followed decreased SOD 0.001) reduced glutathione (GSH) 28. In conclusion, DON-contaminated at (15% final diet days adversely affects immune function, integrity