Decreased putamen activation in balancing goal-directed and habitual behavior in binge eating disorder

• DOI: 10.1016/j.psyneuen.2021.105596
• Publication Date: 2021-11-17T16:22:43Z
• Authors: B. Hartogsveld; C.W.E.M. Quaedflieg; P. van Ruitenbeek; T. Smeets
• Keywords: Putamen; Orbitofrontal cortex; Binge eating; Insular cortex

Acute stress is associated with a shift from goal-directed to habitual behavior. This stress-induced preference for behavior has been suggested as potential mechanism by which binge eating disorder (BED) patients succumb large amounts of high-caloric foods in an uncontrolled manner (i.e., episodes). While healthy subjects the balance between and subserved anterior cingulate cortex (ACC), insular cortex, orbitofrontal (OFC), caudate nucleus, posterior putamen, brain that underlies this (possibly amplified) behavioral BED currently unknown. In current study, 76 participants (38 BED, 38 controls (HCs)) learned six stimulus-response-outcome associations well-established instrumental learning task. Subsequently, three outcomes were selectively devalued, after underwent either induction procedure (Maastricht Stress Test; MAST) or no-stress control procedure. Next, was assessed during functional magnetic resonance imaging. Findings show activity ACC, insula, OFC HCs. Although did not modulate behavior, displayed smaller difference putamen activation trials probing compared HCs when using ROI approach. We conclude differences HC could reflect changes monitoring response accuracy reward value, albeit perhaps sufficiently induce measurable Future research clarify boundary conditions shifts patients.