Diabetes, antidiabetic medications and risk of depression – A population-based cohort and nested case-control study

• DOI: 10.1016/j.psyneuen.2022.105715
• Publication Date: 2022-03-15T07:26:52Z
• Authors: Ida Kim Wium-Ande...; Merete Osler; Martin Balslev Jø...; Jørgen Rungby; Marie Kim Wium-An...
• Keywords: Nested case-control study; Depression

Diabetes type 2 is associated with depression, but the impact of antidiabetic drugs not clear. The objective was to analyze association between diabetes 2, drugs, and depression.This register-based study included 116.699 patients diagnosed from 2000 2012 an age, gender, municipality matched reference group 116.008 individuals without diabetes. All participants were followed for a diagnosis depression or prescription antidepressant medication. Based on this, case-control nested within cohort, using risk set sampling. Antidiabetic medication categorized into insulin, metformin, sulfonylureas glinides combined, glitazones, dipeptidyl peptidase 4 (DPP4) inhibitors, glucagon-like peptide 1 (GLP1) analogs, sodium-glucose transport protein (SGLT2) inhibitors acarbose. analyzed Cox proportional hazards regression, whereas conditional logistic regression used use depression.Patients had higher compared (hazard ratio 1.14 (95% confidence interval 1.14-1.15)). Low doses DPP4 GLP1 SGLT2 lower in non-users, lowest inhibitor users (odds 0.55 (0.44-0.70)). Use sulfonylurea high metformin increased depression. However, specific non-users.