Weight decrease improves live birth rates in obese women undergoing IVF: a pilot study

• DOI: 10.1016/j.rbmo.2017.06.019
• Publication Date: 2017-07-06T07:19:14Z
• Authors: Juan J. Espinós; Ana Polo; Juan Sánchez-Hern...; Ramón Bordas; Pere Pares; Olga Martínez; Joaquim Calaf
• Keywords: Adult; obesity; Pregnancy Rate; Pilot Projects; Fertilization in Vitro; 03 medical and health sciences; 0302 clinical medicine; physical exercise; Pregnancy; Weight Loss; Humans; Obesity; Prospective Studies; Birth Rate; Life Style; 2. Zero hunger; Embryo Transfer; 3. Good health; Pregnancy Complications; IVF; Female; Follicle Stimulating Hormone; diet; Live Birth

Obese women have lower pregnancy rates than normal-weight women undergoing assisted reproductive treatment. We conducted a pilot study to evaluate whether a 12-week diet and exercise intervention before an IVF cycle would influence pregnancy rates in obese women. Forty-one patients were enrolled in this study. They were randomly allocated to two groups: an intervention group (n = 21), who underwent an individualized diet and physical exercise programme supervised by a dietician, and a control group (n = 20), who started IVF with no previous intervention. The primary outcome was clinical pregnancy rate after a single treatment cycle. Mean weight loss in the study group after the intervention was 5.4 kg (range 1.1-14.6 kg). The study and control groups had similar total FSH consumption, number of oocytes and embryos obtained, and number and quality of embryos transferred. There was a non-significant trend towards a higher clinical pregnancy rate after fresh embryo transfer (66.7% versus 41.2%). The intervention group had a significantly higher cumulative live birth rate (61.9% versus 30%, P = 0.045) (odds ratio for intervention group, 3.8; 95% confidence interval, 1.03 to 13.9) The data suggest that weight loss resulted in a significantly increased cumulative live birth rate.