Periconceptional maternal social, lifestyle and medical risk factors impair embryonic growth: The Rotterdam Periconceptional Cohort
0301 basic medicine
Embryonic Development
Fertilization in Vitro
Ultrasonography, Prenatal
3. Good health
03 medical and health sciences
0302 clinical medicine
Pregnancy
Risk Factors
Humans
Female
Prospective Studies
Life Style
Biomarkers
DOI:
10.1016/j.rbmo.2022.02.011
Publication Date:
2022-03-07T04:12:19Z
AUTHORS (6)
ABSTRACT
What is the association between degree of a state maternal vulnerability, determined by suboptimal periconceptional social, lifestyle and medical exposures embryonic growth?In total, 555 pregnancies, comprising 324 naturally conceived pregnancies 231 after IVF intracytoplasmic sperm injection (ICSI) were included from Rotterdam Periconceptional Cohort (Predict Study) November 2010 August 2018. Data on exposures, i.e. vulnerability markers, collected through self-administered questionnaires. To estimate growth, crown-rump length (CRL) volume measurements taken at 7, 9 11 weeks gestation using three-dimensional ultrasound scans virtual reality techniques.Exposure to two or more markers was negatively associated with growth in pregnancies. The CRL trajectories embryos women exposed reduced compared those zero one marker (√CRL: β = -0.29 mm, 95% CI -0.56 -0.02; 3√EV: -0.14 cm3, -0.27 -0.01). These associations not found ICSI.This study showed that higher (CRL volume)
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