Periconceptional maternal social, lifestyle and medical risk factors impair embryonic growth: The Rotterdam Periconceptional Cohort

• DOI: 10.1016/j.rbmo.2022.02.011
• Publication Date: 2022-03-07T04:12:19Z
• Authors: Sofie K.M. van Zu...; Lenie van Rossem; Sten P. Willemsen; Lindsey van der Meer; Hiske E. Ernst-Smelt; Régine P.M. Steeg...
• Keywords: 0301 basic medicine; Embryonic Development; Fertilization in Vitro; Ultrasonography, Prenatal; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Pregnancy; Risk Factors; Humans; Female; Prospective Studies; Life Style; Biomarkers

What is the association between degree of a state maternal vulnerability, determined by suboptimal periconceptional social, lifestyle and medical exposures embryonic growth?In total, 555 pregnancies, comprising 324 naturally conceived pregnancies 231 after IVF intracytoplasmic sperm injection (ICSI) were included from Rotterdam Periconceptional Cohort (Predict Study) November 2010 August 2018. Data on exposures, i.e. vulnerability markers, collected through self-administered questionnaires. To estimate growth, crown-rump length (CRL) volume measurements taken at 7, 9 11 weeks gestation using three-dimensional ultrasound scans virtual reality techniques.Exposure to two or more markers was negatively associated with growth in pregnancies. The CRL trajectories embryos women exposed reduced compared those zero one marker (√CRL: β = -0.29 mm, 95% CI -0.56 -0.02; 3√EV: -0.14 cm3, -0.27 -0.01). These associations not found ICSI.This study showed that higher (CRL volume)