The effect of heart failure on gut microbial richness and diversity

• DOI: 10.1016/j.repc.2022.06.016
• Publication Date: 2023-03-07T21:33:03Z
• Authors: Oguz Kilic; Halil Ibrahim Kaya; Mucahit Secme; Mehmet Kilinc; Cihan Ilyas Sevgican; Ipek Buber; Yavuz Dodurga; Omer Simsek; Cagrı Ergin; Ismail Dogu Kilic
• Keywords: Operational taxonomic unit

With recent advances in genome sequencing technology, a large body of evidence has accumulated over the last few years linking alterations microbiota with cardiovascular disease. In this study, we aimed to compare gut microbial composition using 16S ribosomal DNA (rDNA) techniques patients coronary artery disease (CAD) and stable heart failure (HF) reduced ejection fraction CAD but normal fraction. We also studied relationship between systemic inflammatory markers richness diversity.A total 40 (19 HF CAD, 21 without HF) were included study. was defined as left ventricular <40%. Only ambulatory Gut assessed from participants' fecal samples. The diversity populations each sample by Chao1-estimated OTU number Shannon index.The index similar control groups. There no statistically significant marker levels (tumor necrosis factor-alpha, interleukin 1-beta, endotoxin, C-reactive protein, galectin-3, 6, lipopolysaccharide-binding protein) when analyzed at phylum level.In current compared HF, did not show changes diversity. At genus level Enterococcus sp. more commonly identified patients, addition certain species levels, including increased Lactobacillus letivazi.