Arterial and transcutaneous variability and agreement between multiple successive measurements of carbon dioxide in patients with chronic obstructive lung disease
Male
Chronic obstructive pulmonary disease
Oxygen Inhalation Therapy
Reproducibility of Results
Carbon Dioxide
Middle Aged
Arterial blood gas measurement
Transcutaneous blood gas measurement
Pulmonary Disease, Chronic Obstructive
03 medical and health sciences
0302 clinical medicine
Carbon dioxide
Long-term oxygen therapy
Physiologic monitoring
Humans
Female
Blood Gas Analysis
Respiratory Insufficiency
Blood Gas Monitoring, Transcutaneous
Aged
DOI:
10.1016/j.resp.2020.103486
Publication Date:
2020-06-29T15:43:59Z
AUTHORS (4)
ABSTRACT
This study evaluates agreement between carbon dioxide measured arterial (PaCO2) and transcutaneous (PtcCO2) over time, by repeated successive measures, taking into consideration the inherent variability of arterial measurements.11 patients receiving LTOT, with severe to very severe COPD in a stable phase were studied. Repeated arterial blood samples were drawn and PtcCO2 measured simultaneously at the ear lobe. Bland-Altman analysis was used to evaluate 95 % limits of agreement (LoA). 194 paired samples were analysed. Following correction for bias, the difference between PaCO2 and PtCO2 during dynamic conditions was 0.02 kPa and LoA 0.94 to -0.90 kPa while 29 % of PtCO2 measurements were outside the range of variability for arterial measurements.PtcCO2 corrected for intra-patient bias provide reasonable description of PaCO2 values within but not outside steady state conditions. Our results suggest that PtcCO2 is a valuable method for monitoring in chronic rather than acute conditions when bias can be removed.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (33)
CITATIONS (3)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....