Targeted delivery of inhalable drug particles in the tracheobronchial tree model of a pediatric patient with bronchopneumonia: A numerical study
Adult
Respiratory Aerosols and Droplets
Bronchi
Models, Biological
3. Good health
03 medical and health sciences
0302 clinical medicine
Pharmaceutical Preparations
Administration, Inhalation
Bronchopneumonia
Humans
Computer Simulation
Particle Size
Child
Lung
DOI:
10.1016/j.resp.2023.104024
Publication Date:
2023-01-31T02:46:32Z
AUTHORS (7)
ABSTRACT
Pneumonia is a common cause of hospitalization and death in children worldwide. Inhalation therapy is one of the methods treating pneumonia However, there are limited studies that distinguish between the physiology of children and adults, especially with respect to targeted drug delivery. A tracheobronchial (TB) tree model of an 11-year-old child with bronchopneumonia is selected as a testbed for in silico trials of targeted drug delivery. The airflow and particle transport are solved by the computational fluid dynamics method at an airflow rate of 15 LPM. The results indicate that the distribution of deposited particles shows aggregation on the particle release map. Point-source aerosol release (PSAR) method can significantly reduce the deposition efficiency (DE) of particles in the TB tree model. Specifically, the PSAR method can reduce the DE of large particles (i.e., 7.5 µm and 10 µm) by 7.57% and 9.61%, respectively. This enables rapid design of patient-specific treatment for different population age groups and different airway diseases.
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