A study protocol for a cluster-randomised controlled trial of smartphone-activated first responders with ultraportable defibrillators in out-of-hospital cardiac arrest: The First Responder Shock Trial (FIRST)

• DOI: 10.1016/j.resplu.2023.100466
• Publication Date: 2023-09-06T18:42:10Z
• Authors: Verity Todd; Bridget Dicker; Daniel Okyere; Karen Smith; Tony Smith; Graham Howie; Dion Stub; Michael Ray; Ralph Stewart; Tony Scott; Andy Swain; Natalie Heriot; Aroha Brett; Emily Mahony; Ziad Nehme
• Keywords: First responder; Automated external defibrillator

To describe the First Responder Shock Trial (FIRST), which aims to determine whether equipping frequently responding, smartphone-activated (GoodSAM) first responders with an ultraportable AED can increase 30-day survival rates in OHCA.The FIRST trial is investigator-initiated, bi-national (Victoria, Australia and New Zealand), registry-nested cluster-randomised controlled where unit of randomisation responder. High-frequency GoodSAM are randomised 1:1 receive ultraportable, single-use or standard alert procedures using app.The primary outcome 30 days. The secondary measures (shockable rhythm, return spontaneous circulation, event survival, time shock delivery) routinely collected by OHCA registries both regions. was registered Australian Zealand Clinical Trials Registry (ANZCTR) (Registration: ACTRN12622000448741) on 22 March 2022.The started November 2022 last patient expected be enrolled 2024. We aim detect a 7% proportion survivors, from 9% patients attended control 16% intervention arm. With 80% power, alpha 0.05, cluster size 1.5 coefficient variation for sizes 1, sample required this difference 714 (357 per arm).The study will our understanding potential role portable use community their impact outcomes.