Elevated serum neurologic biomarker profiles after cardiac arrest in a porcine model

• DOI: 10.1016/j.resplu.2024.100726
• Publication Date: 2024-07-20T17:50:45Z
• Authors: Kumaran Senthil; Abhay Ranganathan; Sarah Piel; Marco M. Hefti; Ron W. Reeder; Matthew P. Kirschen; Jonathan Starr; Sarah Morton; Hunter A. Gaudio; Julia C. Slovis; Jeremy R. Herrmann; Robert A. Berg; Todd J. Kilbaugh; Ryan W. Morgan
• Keywords: Neuropathology

Swine exhibit cerebral cortex mitochondrial dysfunction and neuropathologic injury after hypoxic cardiac arrest treated with hemodynamic-directed CPR (HD-CPR) despite normal Cerebral Performance Category scores. We analyzed the temporal evolution of plasma protein biomarkers brain inflammatory cytokines, as well cortical neuropathology for five days following pediatric asphyxia-associated HD-CPR.