Evaluation of pharmacokinetics and safety of a long-term estradiol-releasing stent in rat uterine

• DOI: 10.1016/j.reth.2022.10.001
• Publication Date: 2022-10-21T02:18:12Z
• Authors: Boning Li; Lu Zhang; Yu Xie; Lei Lei; Wenjie Qu; Long Sui
• Keywords: Uterine cavity; Uterine horns

Intrauterine adhesion (IUA), often leading to gynecological complications including amenorrhea, abdominal pain and infertility, is frequently induced by injuries the endometrium. Hence it would be of great benefit take efforts prevent after intrauterine operations. Orally administration 17β-estradiol (E2) commonly used promote endometrium regeneration, but limited low concentrations at injured sites. We aim preparing an E2-releasing uterine stent, which could improve efficiency E2 therapy utilized for IUA prevention.We designed a silicone rubber implanted in cavity continuously release long term. Stents were placed rodent uterine, removed different time points. Remaining stent was measured high performance liquid chromatography (HPLC), organ detected enzyme-linked immuno sorbent assay (ELISA). Endometrium morphology examined histological staining paraffin sections.Our showed controlled over 60 days, significantly increased concentration serum situ uterine. After from rapidly reverted normal level. Also, did not induce pathological changes endometrium.The provided abundant local with satisfactory safety. The based further advanced adjusting its shape load clinical application, might promisingly help lowering incidence IUA.