Autologous concentrated growth factor mediated accelerated bone healing in root-end microsurgery: A multicenter randomized clinical trial

• DOI: 10.1016/j.reth.2023.08.006
• Publication Date: 2023-09-06T17:57:28Z
• Authors: Yoshio Yahata; Keisuke Handa; Naoto Ohkura; Motoki Okamoto; Jun Ohshima; Shusaku Itoh; Nobuyuki Kawashima; Toshinori Tanaka; Nobuya Sato; Yuichiro Noiri; Mikako Hayashi; Takashi Okiji; Masahiro Saito
• Keywords: Medicine (General); R5-920; QH573-671; Root-end microsurgery; Multicenter clinical trial; Regenerative medicine; Concentrated growth factor; Original Article; Cytology; Periapical; 3. Good health

Concentrated growth factor (CGF) is a new-generation autologous platelet concentrate that promotes tissue regeneration and has anti-inflammatory properties. This randomized multicenter trial aimed to evaluate the effects of CGF on bone healing in combination with root-end microsurgery. Healthy adult patients indicated for microsurgery were randomly assigned either or control (no implantation) groups. was implanted into cavity after filling mineral trioxide aggregate. Clinical periapical radiographic evaluations conducted at 1, 3, 6, 12 months postoperatively, follow-up cone-beam computed tomography (CBCT) 6 months. The lesion volume reduction rate calculated based data from preoperative CBCT images. A total 24 enrolled. treatment success 91.7% 83.3% 12-month radiography 6-month CBCT, respectively, without significant difference between two group (75.6%) significantly higher than (61.0%) group. Autologous conjunction accelerated as observed CBCT. Administering blood products stimulate addition removing source infection appears be promising option