Pulmonary amyloidosis diagnosed via transbronchial lung cryobiopsy without surgical lung biopsy: A case series

• DOI: 10.1016/j.rmcr.2022.101688
• Publication Date: 2022-06-20T16:45:35Z
• Authors: Kazushi Fujimoto; Minoru Inomata; Yu Ito; Haruko Matsumoto; Ayae Saiki; Keita Sakamoto; Nobuyasu Awano; Naoyuki Kuse; Toshio Kumasaka; Takehiro Izumo
• Keywords: Amyloid (mycology); Lung biopsy

Pulmonary amyloidosis is a rare disease characterized by abnormal extracellular deposition of amyloid fibril in the lung tissue, and identification deposits essential for its diagnosis. Surgical biopsy (SLB) standard diagnostic method pulmonary amyloidosis. However, it has relatively high post-procedural mortality rate. Recently, transbronchial cryobiopsy (TBLC) been gradually used diagnosing interstitial disease. efficacy not yet validated. Here, we describe two cases with light chain detected via TBLC. Since SLB high-risk procedure patients due to age complications, TBLC was performed. Both presented Congo red-positive deposits. One patient localized had good clinical course without therapeutic intervention followed up. The other systemic received chemotherapy stable course. can collect larger specimen than forceps fewer complications lower rate SLB. Thus, be