Single-cell atlas of domestic pig cerebral cortex and hypothalamus

• DOI: 10.1016/j.scib.2021.04.002
• Publication Date: 2021-04-06T06:04:31Z
• Authors: Jiacheng Zhu; Fang Chen; Lihua Luo; Weiying Wu; Jinxia Dai; Jixing Zhong; Xiumei Lin; Chaochao Chai; Peiwen Ding; Langchao Liang; Shiyou Wang; Xiangning Ding; Yin Chen; Haoyu Wang; Jiaying Qiu; Feiyue Wang; Chengcheng Sun; Yuying Zeng; Jian Fang; Xiaosen Jiang; Ping Liu; Gen Tang; Xin Qiu; Xingliang Zhang; Yetian Ruan; Sanjie Jiang; Jiankang Li; Shida Zhu; Xun Xu; Fang Li; Zhongmin Liu; Gang Cao; Dongsheng Chen
• Keywords: Occipital lobe; Frontal lobe

The brain of the domestic pig (Sus scrofa domesticus) has drawn considerable attention due to its high similarities that humans. However, cellular compositions (PB) remain elusive. Here we investigated single-nucleus transcriptomic profiles five regions PB (frontal lobe, parietal temporal occipital and hypothalamus) identified 21 cell subpopulations. cross-species comparison mouse hypothalamus revealed shared specific gene expression patterns at single-cell resolution. Furthermore, types molecular pathways closely associated with neurological disorders, bridging gap between mutations pathogenesis. We reported, our knowledge, first atlas cerebral cortex combined a comprehensive analysis across species, providing extensive resources for future research regarding neural science, evolutionary developmental biology, regenerative medicine.