Evolutionary trajectory of TRPM2 channel activation by adenosine diphosphate ribose and calcium

• DOI: 10.1016/j.scib.2024.04.052
• Publication Date: 2024-04-26T16:37:16Z
• Authors: Cheng Ma; Yanping Luo; Congyi Zhang; Cheng Cheng; Ning Hua; Xiaocao Liu; Jianan Wu; Luying Qin; Peilin Yu; Jianhong Luo; Fan Yang; Lin-Hua Jiang; Guojie Zhang; Wei Yang
• Keywords: TRPM2; Ribose; Adenosine diphosphate

Ion channel activation upon ligand gating triggers a myriad of biological events and, therefore, evolution mechanism is fundamental importance. TRPM2, typical ancient ion channel, activated by adenosine diphosphate ribose (ADPR) and calcium its has evolved from simple mode in invertebrates to more complex one vertebrates, but the evolutionary process still unknown. Molecular analysis TRPM2s than 280 different animal species revealed that, C-terminal NUDT9-H domain an enzyme binding site for activation, while N-terminal MHR maintains conserved site. Calcium pattern also evolved, Ca