Hypertension modifies the short-term effects of temperature on morbidity of hemorrhagic stroke

• DOI: 10.1016/j.scitotenv.2017.04.159
• Publication Date: 2017-04-22T09:30:20Z
• Authors: Qinzhou Wang; Cuilian Gao; Hongen Liu; Wei Li; Yuying Zhao; Guangrun Xu; Chuanzhu Yan; Hualiang Lin; Lingling Lang
• Keywords: Stroke; China; 03 medical and health sciences; 0302 clinical medicine; Hypertension; Temperature; Humans; Morbidity; Intracranial Hemorrhages; 3. Good health

This study estimated the effects of ambient temperature on hospital admissions for hemorrhagic stroke during 2004-2009 in Jinan, China, and the effect modification of hypertension status.The exposure-response relationship between temperature and hemorrhagic stroke was firstly examined, and then the association between daily mean temperature and hemorrhagic stroke was investigated using a generalized additive model. Stratified analyses were conducted to examine the potential effect modification of hypertension.A total of 1577 hemorrhagic stroke cases were observed between 2004 and 2009, among which, 1058 were hypertensive and 519 were non-hypertensive. We found an approximately linear relationship between ambient temperature and hemorrhagic stroke. Each 1°C decrease in the current day's temperature was associated with 1.63% (95% CI: 0.33%, 2.95%) increase in daily hemorrhagic stroke. The stratified analyses observed that the association was significant among hypertensive hemorrhagic stroke, each 1°C decrease in the current day's temperature was associated with 2.26% (95% CI: 0.57%, 3.98%) increase in daily hypertensive hemorrhagic stroke. While no significant effect was observed for non-hypertensive hemorrhagic stroke.Low temperature might be one risk factor for hemorrhagic stroke and hypertension may be one effect modifier of this association in Jinan, China.