Toxicity of exhaust emissions from high aromatic and non-aromatic diesel fuels using in vitro ALI exposure system

• DOI: 10.1016/j.scitotenv.2023.164215
• Publication Date: 2023-05-23T19:57:43Z
• Authors: Henri Hakkarainen; Anssi Järvinen; Teemu Lepistö; Laura Salo; Niina Kuittinen; Elmeri Laakkonen; Mo Yang; Maria-Viola Marti...; Sanna Saarikoski; Minna Aurela; Luis Barreira; Kimmo Teinilä; Mika Ihalainen; Päivi Aakko-Saksa; Hilkka Timonen; Topi Rönkkö; Pasi Jalava
• Keywords: 570; Air Pollutants; Toxicity; ta1172; 7. Clean energy; 114 Physical sciences; 114; 620; Air-liquid interface; SDG 3 - Good Health and Well-being; 13. Climate action; 11. Sustainability; Engine exhaust; Particulate Matter; SDG 7 - Affordable and Clean Energy; Gases; ta215; ta218; Aromatic; Gasoline; Vehicle Emissions

The differences in the traffic fuels have been shown to affect exhaust emissions and their toxicity. Especially, aromatic content of diesel fuel is an important factor considering emissions, notably particulate matter (PM) concentrations. ultra-fine particles (UFP, with a diameter <100 nm) are components engine connected various health effects, such as pulmonary systematic inflammation, cardiovascular disorders. Studying toxicity UFPs how different options can be used for mitigating crucial. In present study, from heavy-duty were assess emission thermophoresis-based vitro air-liquid interface (ALI) exposure system. aim study was evaluate potential effect 20 % fossil 0 renewable on results show that increases toxicity, which seen increase genotoxicity, distinct inflammatory responses, alterations cell cycle. genotoxicity most likely due PM phase exhaust, exposures high-efficiency absorbing (HEPA)-filtered resulted negligible genotoxicity. However, solely gaseous still elicited immunological responses. Overall, shows decreasing could significant measure