Generation of an induced pluripotent stem cell (iPSC) line from a Parkinson’s disease patient with a pathogenic LRP10/c.688C > T(p.Arg230Trp) mutation

• DOI: 10.1016/j.scr.2024.103359
• Publication Date: 2024-03-03T15:36:26Z
• Authors: Yan Wang; Chuanfei Wei; Yanming Liu; Xianjie Lu; Wei Wang; Na Song; Wei Zhang; Jun Xu; Wei Zhang; Fabin Han
• Keywords: Male; QH301-705.5; Induced Pluripotent Stem Cells; Mutation; Humans; Parkinson Disease; Cell Differentiation; Biology (General); LDL-Receptor Related Proteins; Cell Line

Parkinson's disease (PD) is a highly prevalent and severe neurodegenerative disease that affects more than 10 million individuals worldwide. Pathogenic mutations in LRP10 have been associated with autosomal dominant PD. Here, we report an induced pluripotent stem cell (iPSC) line generated from a PD patient harboring the LRP10 c.688C > T (p.Arg230Trp) variant. Skin fibroblasts from the PD patient were successfully reprogrammed into iPSCs that expressed pluripotency markers, a normal karyotype, and the capacity to differentiate into the three germ layers in vivo. This iPSC line is a potential resource for studying the pathogenic mechanisms of PD.